General Information

  • ID:  hor006804
  • Uniprot ID:  A3FFS8??27-192)
  • Protein name:  Erythropoietin
  • Gene name:  EPO
  • Organism:  Bos mutus grunniens
  • Family:  EPO/TPO family
  • Source:  Human
  • Expression:  Produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos (oxen; cattle); Bos mutus grunniens (Wild yak) (Bos grunniens)
  • GO MF:  GO:0009986 cell surface; GO:0005615 extracellular space
  • GO BP:  GO:0030295 protein kinase activator activity; GO:0005125 cytokine activity; GO:0005128 erythropoietin receptor binding; GO:0005179 hormone activity
  • GO CC:  GO:0001666 response to hypoxia; GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein; GO:0046579 positive regulation of Ras protein signal transduction; GO:0045893 positive regulation of DNA-templated transcription; GO:0008284 positive regulation of cell population proliferation; GO:0000122 negative regulation of transcription by RNA polymerase II; GO:1902251 negative regulation of erythrocyte apoptotic process; GO:0010523 negative regulation of calcium ion transport into cytosol; GO:0042541 hemoglobin biosynthetic process; GO:0038162 erythropoietin-mediated signaling pathway; GO:0043249 erythrocyte maturation; GO:0030218 erythrocyte differentiation; GO:0071474 cellular hyperosmotic response; GO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress; GO:0033028 myeloid cell apoptotic process; GO:0007566 embryo implantation

Sequence Information

  • Sequence:  PARLICDSRVLERYILEAREAENATMGCAEGCSFNENITVPDTKVNFYAWKRMEVQQQAQEVWQGLALLSEAILRGQALLANASQPCEALRLHVDKAVSGLRSLTSLLRALGAQKEAISLPDATPSAAPLRAFTVDALSKLFRIYSNFLRGKLTLYTGEACRRGDR
  • Length:  166
  • Propeptide:  MGARDCTPLLMLSFLLFPLGFPVLGAPARLICDSRVLERYILEAREAENATMGCAEGCSFNENITVPDTKVNFYAWKRMEVQQQAQEVWQGLALLSEAILRGQALLANASQPCEALRLHVDKAVSGLRSLTSLLRALGAQKEAISLPDATPSAAPLRAFTVDALSKLFRIYSNFLRGKLTLYTGEACRRGDR
  • Signal peptide:  MGARDCTPLLMLSFLLFPLGFPVLG
  • Modification:  T30 Sulfocysteine
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific do
  • Mechanism:  Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    NA

Physical Information

Mass: Formula:
Absent amino acids: Common amino acids:
pI: Basic residues:
Polar residues: Hydrophobic residues:
Hydrophobicity: Boman Index:
Half-Life: Half-Life Yeast:
Half-Life E.Coli: Aliphatic Index
Instability Index: Extinction Coefficient cystines:
Absorbance 280nm:

Literature

  • PubMed ID:  NA
  • Title:  NA